Trifluoroacetic acid → HCID 18319070, compound

HRID 1383940Notes

Reaction equation

HRID 1383940 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3](=[O:21])/[CH:4]=[CH:5]/[C:6]1[CH:20]=[CH:19][C:9]([O:10][CH2:11][C:12]([O:14]C(C)(C)C)=[O:13])=[CH:8][CH:7]=1.FC(F)(F)C(O)=O>ClCCl>[F:1][C:2]([F:22])([F:23])[C:3](=[O:21])/[CH:4]=[CH:5]/[C:6]1[CH:20]=[CH:19][C:9]([O:10][CH2:11][C:12]([OH:14])=[O:13])=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86757819HCID 86757819, compound

Product 1

HCID 18319070HCID 18319070, compoundYield 98.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
22 °C

Procedure

A solution of (E)-4-(4,4,4-trifluoro-3-oxo-1-butenyl)phenoxyacetic acid, 1,1-dimethylethyl ester (1.578 g, 4.77 mmol) in dichloromethane (90 ml) was treated with trifluoroacetic acid (10 ml) and stirred at 22° C. for 4 h. The solvent and excess reagent were evaporated under reduced pressure and the last traces of trifluoroacetic acid were co-evaporated with toluene. Crystallization of the residue from ethyl acetate-hexane gave 1.29 g (98%) of the title material as white cubes: mp 156-156.5° C.

Workup

  1. customThe solvent and excess reagent were evaporated under reduced pressure
  2. customCrystallization of the residue from ethyl acetate-hexane

Sources & evidence

ORD record
ord-dae98c4f7d28430f83b91da617502f45
Source dataset
uspto-grants-2001_07
Patent number
US06255496B1

Reaction notes

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