Sodium Iodide → HCID 18319096, compound

HRID 1383953Notes

Reaction equation

HRID 1383953 reaction equation
C[CH:2](Cl)[CH2:3][CH2:4][CH:5]([C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=1)[C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1.[I-:21].[Na+]>CC(=O)CC>[I:21][CH2:2][CH2:3][CH2:4][CH:5]([C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=1)[C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 18319143HCID 18319143, compound

Product 1

HCID 18319096HCID 18319096, compoundYield 93.2%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

A solution of methyl 1-chloro-4,4di-(4-chlorophenyl)butane (1.77 g, 5.64 mmol) in 2-butanone (20 ml) was treated with sodium iodide (1.5 g) and heated under reflux for 18 h. The solid formed was filtered, the filtrate was evaporated and purified on silica gel (elution hexane-toluene 96:5) to give 2.13 g (93%) of the title material as a clear oil.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 18 h
  3. customThe solid formed
  4. filtrationwas filtered
  5. customthe filtrate was evaporated
  6. custompurified on silica gel (elution hexane-toluene 96:5)

Sources & evidence

ORD record
ord-4a635bc57a334797afc7b0f413952335
Source dataset
uspto-grants-2001_07
Patent number
US06255496B1

Reaction notes

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