Ethyl Acetate → Benzimidazole

HRID 1383955Notes

Reaction equation

HRID 1383955 reaction equation
[NH2:1][C:2]1[C:3]([NH2:9])=[C:4](C)[CH:5]=[CH:6][CH:7]=1.[C:10](OCC)(=O)C>>[N:9]1[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[NH:1][CH:10]=1

Participants

3

Reactant 2

HCID 8857Ethyl AcetateHCID 175932,3-Diaminotoluene

Product 1

HCID 5798Benzimidazole

Procedure

Whne diaminotoluene was treated with 4-chlorophenoxynitrile there was no precipitate observed immediately. The reaction mixture was condensed under vacuum. The crude brownish solid was dissolved in ethyl acetate. The resulting solution was washed with water, then brine, and then dried over sodium sulfate. The solvents were then removed in vacuo to produce brown crystals with a good yield.

Workup

  1. customcondensed under vacuum
  2. washThe resulting solution was washed with water
  3. dry with materialbrine, and then dried over sodium sulfate
  4. customThe solvents were then removed in vacuo
  5. customto produce brown crystals with a good yield

Sources & evidence

ORD record
ord-fdf4a84d2cad417aa850790d6a03b867
Source dataset
uspto-grants-2001_07
Patent number
US06255494B1

Reaction notes

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