Hydrochloric Acid → 2,3-Diaminophenol--hydrogen chloride (1/2)
Reaction equation
[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[CH:4][C:3]=1[OH:9].[ClH:10]>C(O)C>[ClH:10].[ClH:10].[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[CH:4][C:3]=1[OH:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 50 °C
Procedure
In a 250 ml single neck round bottom flask was added 2,3-diaminophenol (10 g, 80.55 mmol) to ethanol (100 ml). This mixture was heated to 50° C. to achieve dissolution. The resulting solution is cooled to −5 to 0° C. and an excess of anhydrous hydrogen chloride gas was added to form a viscous slurry. The resulting mixture was stirred for two hours at ˜0° C., then filtered, and rinsed with chilled methanol (30 ml). The solvents were removed in vacuo and the residue was dried overnight.
Workup
- dissolutiondissolution
- temperatureThe resulting solution is cooled to −5 to 0° C.
- customto form a viscous slurry
- filtrationfiltered
- washrinsed with chilled methanol (30 ml)
- customThe solvents were removed in vacuo
- customthe residue was dried overnight
Sources & evidence
- ORD record
- ord-8db2d0d1e5914a8a9fe096d494e21526
- Source dataset
- uspto-grants-2001_07
- Patent number
- US06255494B1
Reaction notes
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