Potassium Carbonate → HCID 178435861, compound

HRID 1384007Notes

Reaction equation

[CH:1]([C:3]1[C:11]2[N:10]=[C:9]([CH2:12][O:13][C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=3)[N:8](S(C(F)(F)F)(=O)=O)[C:7]=2[CH:6]=[CH:5][CH:4]=1)=[CH2:2].C(=O)([O-])[O-].[K+].[K+]>CO>[CH:1]([C:3]1[C:11]2[NH:10][C:9]([CH2:12][O:13][C:14]3[CH:15]=[CH:16][C:17]([Cl:20])=[CH:18][CH:19]=3)=[N:8][C:7]=2[CH:6]=[CH:5][CH:4]=1)=[CH2:2]

Participants

Conditions

Temperature: 0 °C

Procedure

In a 100 ml round bottom flask, under a nitrogen atmosphere, were added 4-(ethenyl)-2-[(4-chlorophenoxy)methyl]-1-trifluoromethanesulfonylbenzimidazole (1.42 g, 3.29 mmol) and anhydrous methanol (20 ml). This solution was cooled to 0° C. and potassium carbonate (911 mg, 6.59 mmol) was added. The resulting mixture was stirred for two hours at 0° C., permitted to warm to room temperature, and stirred at this temperature for about three days. The progress of the reaction was monitored by thin layer chromatography. The desired title product was further purified by radial chromatography.

Workup

temperatureto warm to room temperature
stirringstirred at this temperature for about three days
customThe desired title product was further purified by radial chromatography

Sources & evidence

ORD record: ord-b523f932621e416da722f2896bac7134
Source dataset: uspto-grants-2001_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06255494B1

Reaction notes

Loading…