HRID1384028

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CC(C)(C)OC(=O)N1CCC(CCCn2c(COc3ccc(Cl)cc3)nc3c(OCCCN4CCCCC4CCN4CCCCC4)cccc32)CC1

HCID21188663

未命名化合物

PRODUCTS

生成物

结构：Clc1ccc(OCc2nc3c(OCCCN4CCCCC4CCN4CCCCC4)cccc3n2CCCC2CCNCC2)cc1

HCID21188834

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from (RS) 4-[3-[2-[2-(piperidin-1-yl)ethyl]piperidin-1-yl]propoxy]-2-[(4-chlorophenoxy)methyl]-1-[3-[1-(t-butoxycarbonyl)piperidin-4-yl]propyl]benzimidazole using trifluoroacetic acid deprotection as described supra.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8ba285a8c8aa4d128f9dedeecfd39721
来源数据集: uspto-grants-2001_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06255494B1
来源说明: uspto-grants-2001_07

反应 SMILES

[N:1]1([CH2:7][CH2:8][CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][N:10]2[CH2:15][CH2:16][CH2:17][O:18][C:19]2[C:27]3[N:26]=[C:25]([CH2:28][O:29][C:30]4[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=4)[N:24]([CH2:37][CH2:38][CH2:39][CH:40]4[CH2:45][CH2:44][N:43](C(OC(C)(C)C)=O)[CH2:42][CH2:41]4)[C:23]=3[CH:22]=[CH:21][CH:20]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.FC(F)(F)C(O)=O>>[N:1]1([CH2:7][CH2:8][CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][N:10]2[CH2:15][CH2:16][CH2:17][O:18][C:19]2[C:27]3[N:26]=[C:25]([CH2:28][O:29][C:30]4[CH:31]=[CH:32][C:33]([Cl:36])=[CH:34][CH:35]=4)[N:24]([CH2:37][CH2:38][CH2:39][CH:40]4[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]4)[C:23]=3[CH:22]=[CH:21][CH:20]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1