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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1384030Generated: November 2, 2026

Trifluoroacetic acid → 4-[3-[4-(Methyl)piperidin-1-yl]propoxy]-2-[(4-chlorophenoxy)methyl]-1-[3-(piperidin-4-yl)propyl]benzimidazole

https://huagongshe.com/reaction/1384030

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantHCID 21188652HCID 21188652—
Product4-[3-[4-(Methyl)piperidin-1-yl]propoxy]-2-[(4-chlorophenoxy)methyl]-1-[3-(piperidin-4-yl)propyl]benzimidazoleHCID 21188567—

Reaction Steps

The title compound was prepared from 4-[3-[4-(methyl)piperidin-1-yl]propoxy]-2-[(4-chlorophenoxy)methyl]-1-[3-[1-(t-butoxycarbonyl)piperidin-4-yl]propyl]benzimidazole by standard trifluoroacetic acid deprotection as described supra.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06255494B1
Source datasetuspto-grants-2001_07
ORD IDord-fe822a2b59b14d9787ab06ec64c811c5
Source noteuspto-grants-2001_07