Trifluoroacetic acid → 4-[3-[4-(Methyl)piperidin-1-yl]propoxy]-2-[(4-chlorophenoxy)methyl]-1-[3-(piperidin-4-yl)propyl]benzimidazole

HRID 1384030Notes

Reaction equation

HRID 1384030 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][CH2:10][O:11][C:12]2[C:20]3[N:19]=[C:18]([CH2:21][O:22][C:23]4[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=4)[N:17]([CH2:30][CH2:31][CH2:32][CH:33]4[CH2:38][CH2:37][N:36](C(OC(C)(C)C)=O)[CH2:35][CH2:34]4)[C:16]=3[CH:15]=[CH:14][CH:13]=2)[CH2:4][CH2:3]1.FC(F)(F)C(O)=O>>[CH3:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][CH2:10][O:11][C:12]2[C:20]3[N:19]=[C:18]([CH2:21][O:22][C:23]4[CH:24]=[CH:25][C:26]([Cl:29])=[CH:27][CH:28]=4)[N:17]([CH2:30][CH2:31][CH2:32][CH:33]4[CH2:34][CH2:35][NH:36][CH2:37][CH2:38]4)[C:16]=3[CH:15]=[CH:14][CH:13]=2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 21188652HCID 21188652, compound

Product 1

HCID 211885674-[3-[4-(Methyl)piperidin-1-yl]propoxy]-2-[(4-chlorophenoxy)methyl]-1-[3-(piperidin-4-yl)propyl]benzimidazole

Procedure

The title compound was prepared from 4-[3-[4-(methyl)piperidin-1-yl]propoxy]-2-[(4-chlorophenoxy)methyl]-1-[3-[1-(t-butoxycarbonyl)piperidin-4-yl]propyl]benzimidazole by standard trifluoroacetic acid deprotection as described supra.

Sources & evidence

ORD record
ord-fe822a2b59b14d9787ab06ec64c811c5
Source dataset
uspto-grants-2001_07
Patent number
US06255494B1

Reaction notes

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