HCID 15486863, compound → HCID 10005184, compound

HRID 1384066Notes

Reaction equation

HRID 1384066 reaction equation
[Br:1][C:2]1[CH:25]=[C:24]([C:26]([CH3:28])=[CH2:27])[CH:23]=[C:22]([O:29][CH3:30])[C:3]=1[O:4][C:5]1[C:6]2[N:14]=[N:13][N:12]([CH:15]([CH2:19][CH2:20][CH3:21])[CH2:16][CH2:17][CH3:18])[C:7]=2[N:8]=[C:9]([CH3:11])[N:10]=1>C(O)C.[Pt]>[Br:1][C:2]1[CH:25]=[C:24]([CH:26]([CH3:28])[CH3:27])[CH:23]=[C:22]([O:29][CH3:30])[C:3]=1[O:4][C:5]1[C:6]2[N:14]=[N:13][N:12]([CH:15]([CH2:16][CH2:17][CH3:18])[CH2:19][CH2:20][CH3:21])[C:7]=2[N:8]=[C:9]([CH3:11])[N:10]=1

Participants

4

Reactant 1

HCID 15486863HCID 15486863, compound

Product 1

HCID 10005184HCID 10005184, compound

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 702EthanolSolvent

Procedure

Platinum black, 5% (0.19 g) was added to a solution of 7-[2-bromo-6-methoxy-4-(1-methylethenyl)phenoxy]-5-methyl-3-(1-propylbutyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine (0.17 g) in 50 mL of ethanol. The mixture was hydrogenated at a pressure of 40 psi for 18 hours and filtered through celite. The filtrate was stripped of the solvent under reduced pressure and the residue recrystallized from hexane to yield the title compound as a colorless crystalline solid, mp 129-131° C.

Workup

  1. filtrationfiltered through celite
  2. customthe residue recrystallized from hexane

Sources & evidence

ORD record
ord-b686e20a37c54010b95e1031cfb9c80d
Source dataset
uspto-grants-2001_07
Patent number
US06258809B1

Reaction notes

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