反应详情

Starting from 1.10 g of 3-chloromethyl-5-(4-fluorophenyl)pyridine (“B”) [obtainable, for example, by radical chlorination of 3-methyl-5-(4-fluorophenyl)-pyridine], reaction with 0.82 g of 1-(2-pyrimidinyl)piperazine in 200 ml of acetonitrile at room temperature analogously to Example 1 gives 1-(2-pyrimidinyl)-4-[(5-(4-fluorophenyl)-3-pyridyl)methyl]piperazine, m.p. 97-98°, after customary work-up.