1-(2-Pyrimidinyl)piperazine → HCID 15840855, compound

HRID 1384075Notes

Reaction equation

HRID 1384075 reaction equation
Cl[CH2:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH:8]=1.[N:16]1[CH:21]=[CH:20][CH:19]=[N:18][C:17]=1[N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>C(#N)C>[N:16]1[CH:21]=[CH:20][CH:19]=[N:18][C:17]=1[N:22]1[CH2:27][CH2:26][N:25]([CH2:2][C:3]2[CH:4]=[N:5][CH:6]=[C:7]([C:9]3[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=3)[CH:8]=2)[CH2:24][CH2:23]1

Participants

4

Reactant 2

HCID 887471-(2-Pyrimidinyl)piperazineHCID 109330253-(Chloromethyl)-5-(4-fluorophenyl)pyridine

Product 1

HCID 15840855HCID 15840855, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Starting from 1.10 g of 3-chloromethyl-5-(4-fluorophenyl)pyridine (“B”) [obtainable, for example, by radical chlorination of 3-methyl-5-(4-fluorophenyl)-pyridine], reaction with 0.82 g of 1-(2-pyrimidinyl)piperazine in 200 ml of acetonitrile at room temperature analogously to Example 1 gives 1-(2-pyrimidinyl)-4-[(5-(4-fluorophenyl)-3-pyridyl)methyl]piperazine, m.p. 97-98°, after customary work-up.

Sources & evidence

ORD record
ord-f2da9e9cd66b442c8f10e62ca2177971
Source dataset
uspto-grants-2001_07
Patent number
US06258813B1

Reaction notes

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