HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Pyrimidinyl)piperazine → HCID 15840855, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Pyrimidinyl)piperazine | HCID 88747 | — |
| Reactant | 3-(Chloromethyl)-5-(4-fluorophenyl)pyridine | HCID 10933025 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 15840855 | HCID 15840855 | — |
Reaction Steps
Starting from 1.10 g of 3-chloromethyl-5-(4-fluorophenyl)pyridine (“B”) [obtainable, for example, by radical chlorination of 3-methyl-5-(4-fluorophenyl)-pyridine], reaction with 0.82 g of 1-(2-pyrimidinyl)piperazine in 200 ml of acetonitrile at room temperature analogously to Example 1 gives 1-(2-pyrimidinyl)-4-[(5-(4-fluorophenyl)-3-pyridyl)methyl]piperazine, m.p. 97-98°, after customary work-up.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06258813B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-f2da9e9cd66b442c8f10e62ca2177971 |
| Source note | uspto-grants-2001_07 |