HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Pyrimidinyl)piperazine → 1-Pyrimidin-2-yl-4-[(4'-trifluoromethyl-3-biphenylyl)methyl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Pyrimidinyl)piperazine | HCID 88747 | — |
| Reactant | 3-(4-Trifluoromethylphenyl)-benzyl chloride | HCID 22280138 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Pyrimidin-2-yl-4-[(4'-trifluoromethyl-3-biphenylyl)methyl]piperazine | HCID 21186106 | — |
Reaction Steps
A solution of 1.6 g of 1-pyrimidin-2-ylpiperazine in 200 ml of THF is treated with 2.75 g of 3-chloromethyl-4′-trifluoromethylbiphenyl (“H”) [obtainable, for example, by radical chlorination of 3-methyl-4′-trifluoromethylbiphenyl], dissolved in 30 ml of THF, and the mixture is stirred for 4 hours at room temperature. After customary work-up, 1-pyrimidin-2-yl-4-[(4′-trifluoromethyl-3-biphenylyl)methyl]piperazine is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06258813B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-73c4577747184f069921b035505c399b |
| Source note | uspto-grants-2001_07 |