反应详情

A solution of 1.6 g of 1-pyrimidin-2-ylpiperazine in 200 ml of THF is treated with 2.75 g of 3-chloromethyl-4′-trifluoromethylbiphenyl (“H”) [obtainable, for example, by radical chlorination of 3-methyl-4′-trifluoromethylbiphenyl], dissolved in 30 ml of THF, and the mixture is stirred for 4 hours at room temperature. After customary work-up, 1-pyrimidin-2-yl-4-[(4′-trifluoromethyl-3-biphenylyl)methyl]piperazine is obtained.