Pyridinium chloride → HCID 21186149, compound

HRID 1384077Notes

Reaction equation

HRID 1384077 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][C:16]2[CH:17]=[N:18][CH:19]=[C:20]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH:21]=2)[CH2:11][CH2:10]1.Cl.N1C=CC=CC=1>N1C=CC=CC=1>[OH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][C:16]2[CH:17]=[N:18][CH:19]=[C:20]([C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH:21]=2)[CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 21186092HCID 21186092, compound

Product 1

HCID 21186149HCID 21186149, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 0.6 g of 1-(2-methoxyphenyl)-4-[(5-phenyl-3-pyridyl)methyl]piperazine [obtainable as described for Example 1], 1.8 g of pyridine hydrochloride and 50 ml of pyridine is boiled for 3 hours. The mixture is cooled and evaporated, and work-up is as usual, yielding 1-(2-hydroxyphenyl)-4-[(5-phenyl-3-pyridyl)methyl]piperazine.

Workup

  1. temperatureThe mixture is cooled
  2. customevaporated

Sources & evidence

ORD record
ord-2ce83b3fa5524b9b963fd6067e1af3a4
Source dataset
uspto-grants-2001_07
Patent number
US06258813B1

Reaction notes

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