Lithium hydroxide, monohydrate → 212142-75-1

HRID 1384152Notes

Reaction equation

HRID 1384152 reaction equation
[Cl:1][C:2]1[CH:34]=[CH:33][C:5]([NH:6][C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]([CH:17]([O:24]C(=O)C3C=CC=CC=3)[C:18]3[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=3)=[N:9][N:8]=2)=[CH:4][CH:3]=1.O.[OH-].[Li+]>O1CCOCC1.CO.O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:6][C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]([CH:17]([C:18]3[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=3)[OH:24])=[N:9][N:8]=2)=[CH:33][CH:34]=1

Participants

6

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 53651284HCID 53651284, compound

Product 1

HCID 22386455212142-75-1

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

100 mg (0.214 mMol) of rac benzoic acid-[4-(4-chloroanilino)phthalazin-1-yl](pyridin-4-yl)-methyl ester in 2 ml dioxane, 1 ml methanol and 1 ml water are saponified with 9.9 mg (0.235 mmol) lithium hydroxide monohydrate. After 16 h, the title compound is filtered off: m.p. 196-197° C., FAB MS (M+H)+=363.

Workup

  1. filtrationthe title compound is filtered off

Sources & evidence

ORD record
ord-d54a06aa09f641d58e90c7ff49ada154
Source dataset
uspto-grants-2001_07
Patent number
US06258812B1

Reaction notes

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