HCID 21185885, compound → HCID 21185953, compound

HRID 1384171Notes

Reaction equation

HRID 1384171 reaction equation
[CH3:1][C:2]1([CH3:26])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([C:14]([C:16]3[CH:17]=[C:18]([C:22]([O:24][CH3:25])=[O:23])[CH:19]=[CH:20][CH:21]=3)=[CH2:15])[CH:5]=[CH:4][C:3]1=2.[H][H]>C(OCC)(=O)C.[Pd]>[CH3:26][C:2]1([CH3:1])[CH2:11][CH2:10][C:9]([CH3:12])([CH3:13])[C:8]2[CH:7]=[C:6]([CH:14]([C:16]3[CH:17]=[C:18]([CH:19]=[CH:20][CH:21]=3)[C:22]([O:24][CH3:25])=[O:23])[CH3:15])[CH:5]=[CH:4][C:3]1=2

Participants

5

Reactant 2

HCID 21185885HCID 21185885, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21185953HCID 21185953, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A solution of methyl 3-[1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthyl)vinyl]phenylcarboxylate (1.2 g, 3.45 mmol) in ethyl acetate, in the presence of palladium-on-charcoal (0.3 g) at a pressure of 6 bar of hydrogen, is stirred at room temperature for 4 h. The mixture is filtered through Celite and then concentrated on a rotary evaporator under vacuum at 40° C.

Workup

  1. filtrationThe mixture is filtered through Celite
  2. concentrationconcentrated on a rotary evaporator under vacuum at 40° C.

Sources & evidence

ORD record
ord-28792814ba154f11a1a3e7a52bac8f7d
Source dataset
uspto-grants-2001_07
Patent number
US06258775B1

Reaction notes

Loading…