HCID 21185967, compound → HCID 21185935, compound

HRID 1384173Notes

Reaction equation

HRID 1384173 reaction equation
[CH3:1][C:2]1[C:3]([C:16]([C:18]2[CH:19]=[C:20]([C:24]([O:26][CH3:27])=[O:25])[CH:21]=[CH:22][CH:23]=2)=[CH2:17])=[CH:4][C:5]2[C:6]([CH3:15])([CH3:14])[CH2:7][CH2:8][C:9]([CH3:13])([CH3:12])[C:10]=2[CH:11]=1.[H][H]>C(OCC)(=O)C.[Pd]>[CH3:1][C:2]1[C:3]([CH:16]([C:18]2[CH:19]=[C:20]([CH:21]=[CH:22][CH:23]=2)[C:24]([O:26][CH3:27])=[O:25])[CH3:17])=[CH:4][C:5]2[C:6]([CH3:14])([CH3:15])[CH2:7][CH2:8][C:9]([CH3:12])([CH3:13])[C:10]=2[CH:11]=1

Participants

5

Reactant 2

HCID 21185967HCID 21185967, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21185935HCID 21185935, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A solution of methyl 3-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)vinyl]phenylcarboxylate (2.5 g, 6.9 mmol) in ethyl acetate, in the presence of palladium-on-charcoal (700 mg) at a pressure of 6 bar of hydrogen, is stirred at room temperature for 4 h. The mixture is filtered through Celite and then concentrated on a rotary evaporator under vacuum at 40° C.

Workup

  1. filtrationThe mixture is filtered through Celite
  2. concentrationconcentrated on a rotary evaporator under vacuum at 40° C.

Sources & evidence

ORD record
ord-aa57f867405a4c869dc37f59eb015b78
Source dataset
uspto-grants-2001_07
Patent number
US06258775B1

Reaction notes

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