反应详情

Diiodomethane (1.1 ml, 13.7 mmol) is added dropwise, at 60° C., to a mixture of methyl 3-[1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthyl)vinyl]phenylcarboxylate (2.2 g, 6.3 mmol) and a 1M solution of diethylzinc in heptane (13 ml, 13 mmol) in dichloromethane (50 ml). The heating is continued for 15 h. The solution is extracted with ethyl acetate. After separation of the phases by settling, the organic phase is washed with 1N HCl solution and then with water, dried over anhydrous magnesium sulphate and concentrated.

1. extractionThe solution is extracted with ethyl acetate
2. customAfter separation of the phases
3. washthe organic phase is washed with 1N HCl solution
4. dry with materialwith water, dried over anhydrous magnesium sulphate
5. concentrationconcentrated