Methanol → 2-Amino-5-chloro-3-methoxypyrazine

Sodium (2.82 g) was dissolved in dry methanol (50 ml) under argon and 2-amino-3-bromo-5-chloropyrazine (1.68 g) was added in small portions with stirring. The stirred solution was heated at reflux under an atmosphere of argon for 4 hours. The solution was allowed to cool to ambient temperature and water (10 ml) was added. Volatile material was removed by evaporation and water (10 ml) was added to the residue. The mixture was extracted with dichloromethane (3×50 ml) and the combined extracts were dried (MgSO4) and evaporated to give 2-amino-5-chloro-3-methoxypyrazine (1.28 g), m.p. 102-103° C.; 1H NMR (d6-DMSO): 3.90 (s, 3H), 7.53 (s, 1H); mass spectrum (+ve CI): 160 (M+H)+.

1. temperatureThe stirred solution was heated
2. temperatureat reflux under an atmosphere of argon for 4 hours
3. customVolatile material was removed by evaporation and water (10 ml)
4. additionwas added to the residue
5. extractionThe mixture was extracted with dichloromethane (3×50 ml)
6. dry with materialthe combined extracts were dried (MgSO4)
7. customevaporated

ORD record

ord-5fbe0b4a98e743c687f43f07b5b5581c

Source dataset

uspto-grants-2001_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06258817B1