2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- → HCID 21186750, compound

HRID 1384262Notes

Reaction equation

HRID 1384262 reaction equation
[CH:1]([CH:3]1[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][C:4]1=O)=O.[NH2:11]/[C:12](/[CH3:19])=[CH:13]\[C:14]([O:16][CH2:17][CH3:18])=[O:15]>>[CH3:19][C:12]1[N:11]=[C:4]2[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:3]2=[CH:1][C:13]=1[C:14]([O:16][CH2:17][CH3:18])=[O:15]

Participants

3

Reactant 2

HCID 6437562-Butenoic acid, 3-amino-, ethyl ester, (2Z)-HCID 127346672-Oxocycloheptane-1-carbaldehyde

Product 1

HCID 21186750HCID 21186750, compoundYield 47.8%

Procedure

2-Formylcycloheptanone (1.70 g, 12.1 mmol) and ethyl 3-aminocrotonate (1.58 g, 12.1 mmol) were stirred at 100° C. for 15 hours. After cooling, the reaction solution was purified by a silica gel column chromatography (ether/hexane=1:3) to obtain the title compound (1.35 g, 46.1%) as pale yellow powder.

Workup

  1. temperatureAfter cooling
  2. customthe reaction solution was purified by a silica gel column chromatography (ether/hexane=1:3)

Sources & evidence

ORD record
ord-0d7fdd0a69c24fa299a584255d4f950a
Source dataset
uspto-grants-2001_07
Patent number
US06258829B1

Reaction notes

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