Guanidine Hydrochloride → HCID 178432059, compound

HRID 1384292Notes

Reaction equation

HRID 1384292 reaction equation
C([O:4][CH:5]1[C:11]2=[N:12][C:13]([CH3:21])=[C:14]([C:16](OCC)=[O:17])[CH:15]=[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6]1)(=O)C.Cl.[NH2:23][C:24]([NH2:26])=[NH:25]>>[OH:4][CH:5]1[C:11]2=[N:12][C:13]([CH3:21])=[C:14]([C:16]([NH:25][C:24]([NH2:26])=[NH:23])=[O:17])[CH:15]=[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6]1

Participants

3

Reactant 2

HCID 5742Guanidine HydrochlorideHCID 21186674HCID 21186674, compound

Product 1

HCID 178432059HCID 178432059, compoundYield 58.9%

Procedure

When the method of Inventive Example 1 was repeated using ethyl 9-acetoxy-2-methyl-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine-3-carboxylate (450.0 mg, 1.55 mmol) and guanidine hydrochloride (2.67 g, 28.0 mmol), hydrolysis of the acetoxy group occurred at the same time, and the title compound (237.8 mg, 58.9%) was obtained as white powder.

Sources & evidence

ORD record
ord-89501d3bebf44fe6be6637960f55efac
Source dataset
uspto-grants-2001_07
Patent number
US06258829B1

Reaction notes

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