反应详情

温度

95 °C

The product of EXAMPLE 61 (50 mg) was combined with N,N-dimethylformamide dimethylacetal (4 mL). The reaction was heated to 95° C. and stirred for 90 minutes at which the solution was concentrated in vacuo. Purification by flash chromatography on silica eluted with 0-30% EtOAc in hexane afforded the title compound (E/Z mixture of isomers). HPLC/MS: 560.9 (M+1), 562.9 (M+3); Rt=4.48 min.

1. concentrationwas concentrated in vacuo
2. customPurification by flash chromatography on silica
3. washeluted with 0-30% EtOAc in hexane