Hydrochloric Acid → HCID 18404112, compound

HRID 1384378Notes

Reaction equation

HRID 1384378 reaction equation
[NH2:1][C:2]([C:31]1[CH:32]=[N:33][C:34]([Cl:37])=[CH:35][CH:36]=1)([C:25]1[N:26]([CH3:30])[CH:27]=[N:28][CH:29]=1)[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH2:13][CH:14]1[CH2:16][CH2:15]1)[C:8](=[O:17])[CH:7]=[C:6]2[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([Cl:24])[CH:19]=1.[ClH:38].C(OCC)C>C(Cl)Cl>[ClH:24].[ClH:38].[NH2:1][C:2]([C:31]1[CH:32]=[N:33][C:34]([Cl:37])=[CH:35][CH:36]=1)([C:25]1[N:26]([CH3:30])[CH:27]=[N:28][CH:29]=1)[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH2:13][CH:14]1[CH2:15][CH2:16]1)[C:8](=[O:17])[CH:7]=[C:6]2[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([Cl:24])[CH:19]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 9849901(+)-6-[Amino-(6-Chloro-Pyridin-3-yl)-(3-Methyl-3H-Imidazol-4-yl)-Methyl]-4-(3-Chloro-Phenyl)-1-Cyclopropylmethyl-1H-Quinolin-2-One

Product 1

HCID 18404112HCID 18404112, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (+)-6-[Amino-(6-chloro-pyridin-3-yl)-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-chloro-phenyl)-1-cyclopropylmethyl-1H-quinolin-2-one (0.844 g, 1.59 mmol) in DCM (10 ml) was added a solution of HCl in ethyl ether (1M, 4.77 ml, 4.77 mmol). The slurry solution was stirred for 2 hours. After filtration, the title compound of example 56 was obtained as a white solid (0.78 g, 1.29 mmol, 81.4% yield).

Workup

  1. filtrationAfter filtration

Sources & evidence

ORD record
ord-80de02ed673649199cbb80b9807553a4
Source dataset
uspto-grants-2001_07
Patent number
US06258824B1

Reaction notes

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