2-Bromo-2'-acetonaphthone → 4-Hydroxy-undecanoic acid-2-naphthalen-2-yl-2-oxo-ethyl ester

Participants

Reaction Conditions

Reaction Steps

A suspension of 20.00 g of 2-bromo-2′-acetonaphtone, 18.01 g of 4-hydroxy-undecanoic acid sodium salt, and 0.5 g of tetrabutylammonium bromide in 180 ml of dimethylformamide was stirred for 6 hours at 50° C. Then, the reaction mixture was diluted with ether and washed with water, 2N HCl, saturated sodium bicarbonate, and brine. Then, the mixture was dried, filtered, and evaporated to dryness. The resulting solid was purified by recrystallization to yield 7.92 g of colorless crystals.

Provenance & Evidence