反应详情

温度

50 °C

A suspension of 20.00 g of 2-bromo-2′-acetonaphtone, 18.01 g of 4-hydroxy-undecanoic acid sodium salt, and 0.5 g of tetrabutylammonium bromide in 180 ml of dimethylformamide was stirred for 6 hours at 50° C. Then, the reaction mixture was diluted with ether and washed with water, 2N HCl, saturated sodium bicarbonate, and brine. Then, the mixture was dried, filtered, and evaporated to dryness. The resulting solid was purified by recrystallization to yield 7.92 g of colorless crystals.

1. washwashed with water, 2N HCl, saturated sodium bicarbonate, and brine
2. customThen, the mixture was dried
3. filtrationfiltered
4. customevaporated to dryness
5. customThe resulting solid was purified by recrystallization