反应详情

温度

100 °C

The crude trimetrexate base is dissolved in a mixture of DMF and water, preferably in a v/v ratio of about 10:1. The solution is initially heated to about 100° C., then a polar component such as an alcohol, preferably ethanol, is added as the solution cools to about 55-60° C. where crystallization occurs. The resulting crystals are then washed with ethanol to yield a pure trimetrexate DMF adduct. This trimetrexate-DMF adduct is itself a novel compound and is included within the scope of the invention.

1. customcools to about 55-60° C.
2. customwhere crystallization
3. washThe resulting crystals are then washed with ethanol