反应详情

A solution of 6-methoxy-4-phenoxy-7-(4-pyridylmethoxy)quinazoline (200 mg, 0.56 mmol) in 2M hydrochloric acid (15 ml) was heated at reflux for 90 minutes. The reaction mixture was allowed to cool and neutralised to pH6-7 with aqueous ammonia. The precipitated product was extracted with methanol/methylene chloride (1:9) and the extract solution dried (MgSO4). Removal of the solvent by evaporation gave 6-methoxy-7-(4-pyridylmethoxy)-3,4-dihydroquinazolin-4-one (90 mg, 57%) as a grey solid. 1H NMR Spectrum: (DMSOd6) 3.93(s, 3H); 5.35(s, 2H); 7.18(s, 1H); 7.48(s, 1H); 7.50(m, 2H); 8.04(s, 1H); 8.62(m, 2H) MS-ESI: 284 [MH]+

1. temperatureat reflux for 90 minutes
2. temperatureto cool
3. extractionThe precipitated product was extracted with methanol/methylene chloride (1:9)
4. dry with materialthe extract solution dried (MgSO4)
5. customRemoval of the solvent
6. customby evaporation