HCID 22624918, compound → HCID 22624886, compound

Participants

Reaction Steps

A solution of 1-[3-(tetrahydropyran-2-yloxy)propyl]-1,4-dihydro-4-pyridone (0.75 g, 3.16 mmol) in acetic acid (8 ml), THF (4 ml) and water (4 ml) was heated at 50° C. for 4 hours. The volatiles were removed by evaporation to give 1-(3-hydroxypropyl)-1,4-dihydro-4-pyridone (480 mg, 99%) as an off-white solid. 1H NMR Spectrum: (DMSOd6) 1.9-1.95(m, 2H); 1.97-2.05(m, 2H); 4.0-4.1(m, 2H); 6.91(m, 2H); 8.36(m, 2H) MS-ESI: 154 [MH]+

Provenance & Evidence