HCID 22624918, compound → HCID 22624886, compound

HRID 1384546Notes

Reaction equation

HRID 1384546 reaction equation
O1CCCCC1[O:7][CH2:8][CH2:9][CH2:10][N:11]1[CH:16]=[CH:15][C:14](=[O:17])[CH:13]=[CH:12]1>C(O)(=O)C.C1COCC1.O>[OH:7][CH2:8][CH2:9][CH2:10][N:11]1[CH:12]=[CH:13][C:14](=[O:17])[CH:15]=[CH:16]1

Participants

5

Reactant 1

HCID 22624918HCID 22624918, compound

Product 1

HCID 22624886HCID 22624886, compoundYield 99.2%

Reagents, catalysts & solvents 3

HCID 176Acetic AcidSolventHCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 1-[3-(tetrahydropyran-2-yloxy)propyl]-1,4-dihydro-4-pyridone (0.75 g, 3.16 mmol) in acetic acid (8 ml), THF (4 ml) and water (4 ml) was heated at 50° C. for 4 hours. The volatiles were removed by evaporation to give 1-(3-hydroxypropyl)-1,4-dihydro-4-pyridone (480 mg, 99%) as an off-white solid. 1H NMR Spectrum: (DMSOd6) 1.9-1.95(m, 2H); 1.97-2.05(m, 2H); 4.0-4.1(m, 2H); 6.91(m, 2H); 8.36(m, 2H) MS-ESI: 154 [MH]+

Workup

  1. customThe volatiles were removed by evaporation

Sources & evidence

ORD record
ord-ad29ba3cc0a848068a1d89bea836ab9b
Source dataset
uspto-grants-2001_07
Patent number
US06258951B1

Reaction notes

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