HCID 22625095, compound → HCID 22624935, compound

HRID 1384549Notes

Reaction equation

HRID 1384549 reaction equation
O1CCCCC1[O:7][CH2:8][CH2:9][N:10]1[CH:15]=[CH:14][C:13](=[O:16])[CH:12]=[CH:11]1>C(O)(=O)C.C1COCC1.O>[OH:7][CH2:8][CH2:9][N:10]1[CH:15]=[CH:14][C:13](=[O:16])[CH:12]=[CH:11]1

Participants

5

Reactant 1

HCID 22625095HCID 22625095, compound

Product 1

HCID 22624935HCID 22624935, compoundYield 71.2%

Reagents, catalysts & solvents 3

HCID 176Acetic AcidSolventHCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 1-[2-(tetrahydropyran-2-yloxy)ethyl]-1,4-dihydro-4-pyridone (500 mg, 2.23 mmol) in acetic acid (4 ml), THF (2 ml) and water (1 ml) was heated at 45° C. for 4 hours. The volatiles were removed by evaporation to give 1-(2-hydroxyethyl)-1,4-dihydro-4-pyridone (221 mg, 71%) as an off-white solid. 1H NMR Spectrum: (DMSOd6) 3.70(t, 2H); 4.06(t, 2H); 6.95(d, 2H); 8.37(d, 2H)

Workup

  1. customThe volatiles were removed by evaporation

Sources & evidence

ORD record
ord-7b20d5617fcd48f8a0038867c64181e4
Source dataset
uspto-grants-2001_07
Patent number
US06258951B1

Reaction notes

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