Hydrochloric Acid → HCID 66756432, compound

HRID 1384719Notes

Reaction equation

HRID 1384719 reaction equation
[ClH:1].C(OC(N1C=CC=C(C(OC(C)(C)C)=O)N1)=O)C1C=CC=CC=1.[CH3:25][O:26][C:27](=[O:49])[CH2:28][N:29]1[C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][C:34]=2[NH:33][CH2:32][C@H:31]([NH:40]C(OC(C)(C)C)=O)[C:30]1=[O:48]>C(Cl)Cl>[ClH:1].[CH3:25][O:26][C:27](=[O:49])[CH2:28][N:29]1[C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][C:34]=2[NH:33][CH2:32][C@H:31]([NH2:40])[C:30]1=[O:48]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 18465656HCID 18465656, compoundHCID 54305289(3S)-2-Oxo-3-tert-butoxycarbonylamino-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetic acid methyl ester

Product 1

HCID 66756432HCID 66756432, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Anhydrous HCl was bubbled into a solution of 3S) -2-oxo-3-tert-butoxycarbonylamino-2, 3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetic acid methyl ester (600a/103, 4.0 g, 11.4 mmol) in 20 ml of CH2Cl2 for 20 min then stirred for 1 h at RT. The reaction was evaporated to give (3S)-2-oxo-3-amino-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetic acid methyl ester hydrochloride as a white solid.

Workup

  1. customThe reaction was evaporated

Sources & evidence

ORD record
ord-05d4d4cdc77b448eaa14caccb69bb3cd
Source dataset
uspto-grants-2001_07
Patent number
US06258948B1

Reaction notes

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