Hydrochloric Acid → HCID 69637521, compound

HRID 1384755Notes

Reaction equation

HRID 1384755 reaction equation
[OH:1][CH:2]([CH2:16][NH:17][CH:18]([CH3:20])[CH3:19])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([O:14]C)=[O:13])=[CH:7][CH:6]=1.[ClH:21]>>[ClH:21].[OH:1][CH:2]([CH2:16][NH:17][CH:18]([CH3:20])[CH3:19])[CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([CH2:11][C:12]([OH:14])=[O:13])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 12941056HCID 12941056, compound

Product 1

HCID 69637521HCID 69637521, compound

Procedure

A solution of methyl 4-[2-hydroxy-3-[(1-methyl-ethyl)amino]propoxy]phenylacetate (563 mg, 2.00 mmol) in 6M hydrochloric acid (15 ml) was heated at 100° C. for 4 hours. The reaction mixture was concentrated (rotavapor) and the residue was taken up in water and lyophilised. 1H and 13C NMR spectra were in accordance with the strucure and MALDI mass spectrometry gave a M+H at 268 as expected.

Workup

  1. concentrationThe reaction mixture was concentrated (rotavapor)
  2. customgave a M+H at 268

Sources & evidence

ORD record
ord-789c05c98f6c4411b209e644eb92cb73
Source dataset
uspto-grants-2001_07
Patent number
US06261537B1

Reaction notes

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