Acetic Acid → HCID 21183740, compound

Participants

Reaction Steps

A solution of 10 g (28 mmol) of 8-chloro-5-methyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetonitrile in a mixture of 200 ml of concentrated hydrochloric acid and of 200 ml of acetic acid is heated at 100° C. for 4 h. The solution is concentrated under reduced pressure, the residue is taken up in 250 ml of water and the precipitate is collected by filtration. It is washed with water and dried under reduced pressure. 10.2 g (27 mmol) of solid are obtained.

Provenance & Evidence