Acetic Acid → HCID 21183740, compound

HRID 1384809Notes

Reaction equation

HRID 1384809 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]2[N:7]([CH3:11])[C:6]3[C:12](=[O:25])[N:13]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)[N:14]=[C:15](CC#N)[C:5]=3[C:4]=2[CH:3]=1.[C:26]([OH:29])(=[O:28])[CH3:27]>Cl>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]2[N:7]([CH3:11])[C:6]3[C:12](=[O:25])[N:13]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)[N:14]=[C:15]([CH2:27][C:26]([OH:29])=[O:28])[C:5]=3[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 21183755HCID 21183755, compound

Product 1

HCID 21183740HCID 21183740, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 10 g (28 mmol) of 8-chloro-5-methyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetonitrile in a mixture of 200 ml of concentrated hydrochloric acid and of 200 ml of acetic acid is heated at 100° C. for 4 h. The solution is concentrated under reduced pressure, the residue is taken up in 250 ml of water and the precipitate is collected by filtration. It is washed with water and dried under reduced pressure. 10.2 g (27 mmol) of solid are obtained.

Workup

  1. concentrationThe solution is concentrated under reduced pressure
  2. filtrationthe precipitate is collected by filtration
  3. washIt is washed with water
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-0c543e41b4a6490a9646e35674fde6db
Source dataset
uspto-grants-2001_07
Patent number
US06262045B1

Reaction notes

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