反应详情

The preparation is carried out as in Example 1.1, from 20 g (79 mmol) of methyl 4-bromo-1H-indole-2-carboxylate, from 3.8 g of 60% sodium hydride and from 6 ml of iodomethane. After reaction, the solvent is evaporated under reduced pressure and the residue is taken up in water. The mixture is extracted with ethyl acetate. The organic phase is dried and the solvent is evaporated under reduced pressure. The product is dried under reduced pressure. 20.6 g (77 mmol) of solid are obtained.

1. customAfter reaction
2. customthe solvent is evaporated under reduced pressure
3. extractionThe mixture is extracted with ethyl acetate
4. customThe organic phase is dried
5. customthe solvent is evaporated under reduced pressure
6. customThe product is dried under reduced pressure