Methanol → HCID 14039945, compound

HRID 1384880Notes

Reaction equation

HRID 1384880 reaction equation
[CH2:1]1[C:10]2[CH:5]([CH2:6][CH2:7][CH:8]3C=[CH:13][CH:12]=[CH:11][C:9]3=2)[NH:4][CH2:3][CH2:2]1.[CH3:15][OH:16]>>[OH:16][C:15]1[C:8]2[CH2:7][CH2:6][C@H:5]3[C@H:10]([CH2:1][CH2:2][CH2:3][N:4]3[CH2:12][CH2:11][C:9]3[CH:10]=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:9]=2[CH:11]=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 887MethanolHCID 67192496HCID 67192496, compound

Product 1

HCID 14039945HCID 14039945, compoundYield 46%

Procedure

Cis-(−)-7-hydroxy4-phenethyl-1,2,3,4,4a,5,6, 10b)-octahydrobenzo[f]quinoline (hereinafter, “cis-(−)-25”) was prepared in 46% yield from 34 mg (0.11 mmole) of cis-(−-24 by the method described for trans-9 in Example 3. The melting point observed was 196° C. and [α]D (20° C.) was −6.0 (c 0.20, MeOH).

Workup

  1. customobserved was 196° C.
  2. custom[α]D (20° C.)

Sources & evidence

ORD record
ord-c601850acf95455c8ad41d84aa06ff6f
Source dataset
uspto-grants-2001_07
Patent number
US06262064B1

Reaction notes

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