反应详情

A mixture comprising 338 mg of 2-chloro-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline, 435 mg of morpholine and 20 ml of isopropyl alcohol was heated under reflux for 3 hours, followed by the addition of 30 ml of water under heating. The precipitate thus formed was recovered by filtration and washed with 30 ml of water and 30 ml of ethyl acetate. Thus, 310 mg of the title compound was obtained.

1. temperaturewas heated
2. temperatureunder reflux for 3 hours
3. temperatureunder heating
4. customThe precipitate thus formed
5. filtrationwas recovered by filtration
6. washwashed with 30 ml of water and 30 ml of ethyl acetate