Hydrochloric Acid → HCID 70235610, compound

HRID 1384923Notes

Reaction equation

HRID 1384923 reaction equation
[OH-].[Na+].C([O:5][C:6]([CH:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:15]=[CH:16][C:17]3[CH:23]=[CH:22][CH2:21][N:20]([NH:24][CH2:25][C:26]4[CH:31]=[CH:30][C:29]5[O:32][CH2:33][O:34][C:28]=5[CH:27]=4)[C:18]=3[N:19]=2)[CH2:10][CH2:9]1)=[O:7])C.Cl.O>C(O)C>[C:6]([CH:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:15]=[CH:16][C:17]3[CH:23]=[CH:22][CH2:21][N:20]([NH:24][CH2:25][C:26]4[CH:31]=[CH:30][C:29]5[O:32][CH2:33][O:34][C:28]=5[CH:27]=4)[C:18]=3[N:19]=2)[CH2:10][CH2:9]1)([OH:7])=[O:5]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 70191874HCID 70191874, compound

Product 1

HCID 70235610HCID 70235610, compoundYield 76.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.56 ml of 1N sodium hydroxide was added to a solution of 170 mg of 2-(4-ethoxycarbonylpiperidino)-8(3,4-methylenedioxybenzyl)aminopyrido[2,3-d]pyrimidine in 10 ml of ethanol. The obtained mixture was stirred at room temperature for 6 hours and neutralized by the addition of 1N hydrochloric acid and water. The crystals thus precipitated were recovered by filtration, whereby 121 mg of the title compound was obtained.

Workup

  1. customThe crystals thus precipitated
  2. filtrationwere recovered by filtration

Sources & evidence

ORD record
ord-c8f7a9fb66954ec5b6d56a70b623c494
Source dataset
uspto-grants-2001_07
Patent number
US06262059B1

Reaction notes

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