HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → HCID 21183952, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline | HCID 616267 | — |
| Reactant | 1,2-Oxazole-4-carbonyl chloride | HCID 12905114 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 21183952 | HCID 21183952 | — |
Reaction Steps
A solution of isoxazole-4-carbonyl chloride (1.06 g., 8.08 mmole) in dioxane (8 ml.) was added to a solution at of 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline (2.34 g., 8.08 mmole) in dioxane (200 ml.). The mixture was stirred at room temperature for 20 hours. Filtration gave the title compound, which, after recrystallization from methanol, had a m.p. of 225°-260° C. with decomposition.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06262059B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-4802d156c2db478c850b93052b64d25a |
| Source note | uspto-grants-2001_07 |