2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → HCID 21183952, compound

HRID 1384937Notes

Reaction equation

HRID 1384937 reaction equation
[O:1]1[CH:5]=[C:4]([C:6]([Cl:8])=[O:7])[CH:3]=[N:2]1.[NH2:9][C:10]1[C:19]2[C:14](=[CH:15][C:16]([O:22][CH3:23])=[C:17]([O:20][CH3:21])[CH:18]=2)[N:13]=[C:12]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[N:11]=1>O1CCOCC1>[ClH:8].[NH2:9][C:10]1[C:19]2[C:14](=[CH:15][C:16]([O:22][CH3:23])=[C:17]([O:20][CH3:21])[CH:18]=2)[N:13]=[C:12]([N:24]2[CH2:29][CH2:28][N:27]([C:6]([C:4]3[CH:3]=[N:2][O:1][CH:5]=3)=[O:7])[CH2:26][CH2:25]2)[N:11]=1

Participants

4

Reactant 2

HCID 6162672-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazolineHCID 129051141,2-Oxazole-4-carbonyl chloride

Product 1

HCID 21183952HCID 21183952, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of isoxazole-4-carbonyl chloride (1.06 g., 8.08 mmole) in dioxane (8 ml.) was added to a solution at of 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline (2.34 g., 8.08 mmole) in dioxane (200 ml.). The mixture was stirred at room temperature for 20 hours. Filtration gave the title compound, which, after recrystallization from methanol, had a m.p. of 225°-260° C. with decomposition.

Workup

  1. filtrationFiltration

Sources & evidence

ORD record
ord-4802d156c2db478c850b93052b64d25a
Source dataset
uspto-grants-2001_07
Patent number
US06262059B1

Reaction notes

Loading…