反应详情

温度

20 °C

A solution of oxazole-4-carbonyl chloride (0.73 g., 5.53 mmole) in dioxane was added to a solution of 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline (1.60 g., 5.53 mmole) in dioxane. The mixture was heated at reflux for 0.5 hour, then was stirred at 20° C. for 64 hours. Filtration gave the title compound having a m.p. of 291°-294° C. with decomposition after recrystallization from aqueous ethanol.

1. temperatureThe mixture was heated
2. temperatureat reflux for 0.5 hour
3. filtrationFiltration