HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → 4-Amino-6,7-dimethoxy-2-[4-(2-methyloxazole-4-carbonyl)piperazin-1-yl]quinazoline Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline | HCID 616267 | — |
| Reactant | 2-Methyl-1,3-oxazole-4-carbonyl chloride | HCID 14659062 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-Amino-6,7-dimethoxy-2-[4-(2-methyloxazole-4-carbonyl)piperazin-1-yl]quinazoline Hydrochloride | HCID 21184048 | — |
Reaction Steps
A solution of 2-methyloxazole-4-carbonyl chloride (1.01 g., 6.9 mmole) in dioxane was added to a solution of 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline (2.00 g., 6.9 mmole) in dioxane. The mixture was heated at reflux for 2 hours. Filtration gave the title compound having a m.p. of 278°-280° C. with decomposition after recrystallization from methanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06262059B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-aaec32a4b2214f909270ef451d8ddbc9 |
| Source note | uspto-grants-2001_07 |