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HRID1384941

反应详情

EQUATION

反应方程式

HRID 1384941 的结构方程式

REACTANTS

反应物

2
结构：COc1cc2nc(N3CCNCC3)nc(N)c2cc1OC
HCID616267

2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline

C14H19N5O2

结构：Cc1nc(C(=O)Cl)co1
HCID14659062

2-Methyl-1,3-oxazole-4-carbonyl chloride

C5H4ClNO2

PRODUCTS

生成物

1
结构：COc1cc2nc(N3CCN(C(=O)c4coc(C)n4)CC3)nc(N)c2cc1OC.Cl
HCID21184048

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

2 次

PROCEDURE

实验过程

A solution of 2-methyloxazole-4-carbonyl chloride (1.01 g., 6.9 mmole) in dioxane was added to a solution of 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline (2.00 g., 6.9 mmole) in dioxane. The mixture was heated at reflux for 2 hours. Filtration gave the title compound having a m.p. of 278°-280° C. with decomposition after recrystallization from methanol.

WORKUP

后处理

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 2 hours
  3. filtrationFiltration