2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → HCID 21183990, compound

HRID 1384943Notes

Reaction equation

HRID 1384943 reaction equation
[S:1]1[CH:5]=[C:4]([C:6]([Cl:8])=[O:7])[CH:3]=[N:2]1.[NH2:9][C:10]1[C:19]2[C:14](=[CH:15][C:16]([O:22][CH3:23])=[C:17]([O:20][CH3:21])[CH:18]=2)[N:13]=[C:12]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[N:11]=1>>[ClH:8].[NH2:9][C:10]1[C:19]2[C:14](=[CH:15][C:16]([O:22][CH3:23])=[C:17]([O:20][CH3:21])[CH:18]=2)[N:13]=[C:12]([N:24]2[CH2:29][CH2:28][N:27]([C:6]([C:4]3[CH:3]=[N:2][S:1][CH:5]=3)=[O:7])[CH2:26][CH2:25]2)[N:11]=1

Participants

3

Reactant 2

HCID 6162672-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazolineHCID 211840541,2-Thiazole-4-carbonyl chloride

Product 1

HCID 21183990HCID 21183990, compound

Procedure

The title compound was prepared from isothiazole-4-carbonyl chloride (1.01 g.) and 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline (1.99 g.) following previously described procedures. The product had a m.p. of 286°-287° C. with decomposition.

Sources & evidence

ORD record
ord-7ac4e07b42f145f08525e24830da3c64
Source dataset
uspto-grants-2001_07
Patent number
US06262059B1

Reaction notes

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