2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → HCID 21183950, compound

HRID 1384946Notes

Reaction equation

HRID 1384946 reaction equation
[CH3:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([Cl:9])=[O:8])[N:6]=1.[NH2:10][C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:23][CH3:24])=[C:18]([O:21][CH3:22])[CH:19]=2)[N:14]=[C:13]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[N:12]=1>>[ClH:9].[NH2:10][C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:23][CH3:24])=[C:18]([O:21][CH3:22])[CH:19]=2)[N:14]=[C:13]([N:25]2[CH2:30][CH2:29][N:28]([C:7]([C:5]3[N:6]=[C:2]([CH3:1])[S:3][CH:4]=3)=[O:8])[CH2:27][CH2:26]2)[N:12]=1

Participants

3

Reactant 2

HCID 6162672-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazolineHCID 211839592-Methyl-1,3-thiazole-4-carbonyl chloride

Product 1

HCID 21183950HCID 21183950, compound

Procedure

The title compound was prepared from 2-methylthiazole-4-carbonyl chloride (0.49 g.) and 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline (0.87 g.) following previously described procedures. The product had a m.p. of 260°-263° C. with decomposition.

Sources & evidence

ORD record
ord-51de389090e547afafb06a78533ad564
Source dataset
uspto-grants-2001_07
Patent number
US06262059B1

Reaction notes

Loading…