2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → 4-Amino-6,7-dimethyoxy-2-[4-(2-methylthiazole-5-carbonyl)-piperazin-1-yl]quinazoline Hydrochloride

HRID 1384948Notes

Reaction equation

HRID 1384948 reaction equation
[CH3:1][C:2]1[S:3][C:4]([C:7]([Cl:9])=[O:8])=[CH:5][N:6]=1.[NH2:10][C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:23][CH3:24])=[C:18]([O:21][CH3:22])[CH:19]=2)[N:14]=[C:13]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[N:12]=1>>[ClH:9].[NH2:10][C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:23][CH3:24])=[C:18]([O:21][CH3:22])[CH:19]=2)[N:14]=[C:13]([N:25]2[CH2:30][CH2:29][N:28]([C:7]([C:4]3[S:3][C:2]([CH3:1])=[N:6][CH:5]=3)=[O:8])[CH2:27][CH2:26]2)[N:12]=1

Participants

3

Reactant 2

HCID 6162672-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazolineHCID 147162052-Methyl-1,3-thiazole-5-carbonyl chloride

Product 1

HCID 211839814-Amino-6,7-dimethyoxy-2-[4-(2-methylthiazole-5-carbonyl)-piperazin-1-yl]quinazoline Hydrochloride

Procedure

The title compound was prepared from 2-methylthiazole-5-carbonyl chloride (0.42 g.) and 4-amino-6,7-dimethyoxy-2-(1-piperazinyl)-quinazoline (0.75 g.) following previously described procedures. The product had a m.p. of 294°-297° C. with decomposition.

Sources & evidence

ORD record
ord-b287a821fcb9411093e4a89d253c075c
Source dataset
uspto-grants-2001_07
Patent number
US06262059B1

Reaction notes

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