2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → 4-Amino-6,7-dimethoxy-2-[4-(4-methylthiazole-5-carbonyl)-piperazin-1-yl]quinazoline hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline	HCID 616267	—
Reactant	4-Methyl-1,3-thiazole-5-carbonyl chloride	HCID 12470210	—
Product	4-Amino-6,7-dimethoxy-2-[4-(4-methylthiazole-5-carbonyl)-piperazin-1-yl]quinazoline hydrochloride	HCID 21184016	—

Reaction Steps

The title compound was prepared from 4-methylthiazole-5-carbonyl chloride (1.1 g.) and 4-amino-6,7-dimethyoxy-2-(1-piperazinyl)quinazoline (2.0 g.) following previously described procedures. The product had a m.p. of 293°-295° C. with decomposition.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06262059B1
Source dataset	uspto-grants-2001_07
ORD ID	ord-968eaa645ff1486faeac2debc96542e5
Source note	uspto-grants-2001_07