2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → 4-Amino-6,7-dimethoxy-2-[4-(4-methylthiazole-5-carbonyl)-piperazin-1-yl]quinazoline hydrochloride

HRID 1384949Notes

Reaction equation

HRID 1384949 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1[C:7]([Cl:9])=[O:8].[NH2:10][C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:23][CH3:24])=[C:18]([O:21][CH3:22])[CH:19]=2)[N:14]=[C:13]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[N:12]=1>>[ClH:9].[NH2:10][C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:23][CH3:24])=[C:18]([O:21][CH3:22])[CH:19]=2)[N:14]=[C:13]([N:25]2[CH2:30][CH2:29][N:28]([C:7]([C:6]3[S:5][CH:4]=[N:3][C:2]=3[CH3:1])=[O:8])[CH2:27][CH2:26]2)[N:12]=1

Participants

3

Reactant 2

HCID 6162672-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazolineHCID 124702104-Methyl-1,3-thiazole-5-carbonyl chloride

Product 1

HCID 211840164-Amino-6,7-dimethoxy-2-[4-(4-methylthiazole-5-carbonyl)-piperazin-1-yl]quinazoline hydrochloride

Procedure

The title compound was prepared from 4-methylthiazole-5-carbonyl chloride (1.1 g.) and 4-amino-6,7-dimethyoxy-2-(1-piperazinyl)quinazoline (2.0 g.) following previously described procedures. The product had a m.p. of 293°-295° C. with decomposition.

Sources & evidence

ORD record
ord-968eaa645ff1486faeac2debc96542e5
Source dataset
uspto-grants-2001_07
Patent number
US06262059B1

Reaction notes

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