Sodium → HCID 15541137, compound

HRID 1384973Notes

Reaction equation

HRID 1384973 reaction equation
C([O:4][C:5]1[C:10]([CH3:11])=[CH:9][C:8]([O:12][CH2:13][C:14]([F:17])([F:16])[F:15])=[CH:7][C:6]=1[CH3:18])(=O)C.[Na]>CO>[CH3:11][C:10]1[CH:9]=[C:8]([O:12][CH2:13][C:14]([F:15])([F:16])[F:17])[CH:7]=[C:6]([CH3:18])[C:5]=1[OH:4]

Participants

4

Reactant 2

HCID 5360545SodiumHCID 15541136HCID 15541136, compound

Product 1

HCID 15541137HCID 15541137, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The 2,6-dimethyl-4-(2,2,2-trifluoroethoxy)phenyl acetate (733 mg, 2.80 mmol) in methanol (10 mL) was treated with sodium metal and stirred at room temperature overnight. The solvent was removed and the residue partitioned between ethyl acetate and water. The organic layer was washed twice with brine and dried. The solvent was removed to give 2,6-dimethyl-4-(2,2,2-trifluoroethoxy)phenol.

Workup

  1. customThe solvent was removed
  2. customthe residue partitioned between ethyl acetate and water
  3. washThe organic layer was washed twice with brine
  4. customdried
  5. customThe solvent was removed

Sources & evidence

ORD record
ord-389f442dc0bc430ebfc61419d9b0357d
Source dataset
uspto-grants-2001_07
Patent number
US06262078B1

Reaction notes

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