Hydrochloric Acid → 3-(4-Bromo-2,6-dimethylphenoxymethyl)-1-methylpiperidine hydrochloride

HRID 1384980Notes

Reaction equation

HRID 1384980 reaction equation
[Br:1][C:2]1[CH:16]=[C:15]([CH3:17])[C:5]([O:6][CH2:7][CH:8]2[CH2:13][CH2:12][CH2:11][N:10]([CH3:14])[CH2:9]2)=[C:4]([CH3:18])[CH:3]=1.[ClH:19]>CCOCC>[ClH:19].[Br:1][C:2]1[CH:16]=[C:15]([CH3:17])[C:5]([O:6][CH2:7][CH:8]2[CH2:13][CH2:12][CH2:11][N:10]([CH3:14])[CH2:9]2)=[C:4]([CH3:18])[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 99486563-(4-Bromo-2,6-dimethylphenoxymethyl)-1-methylpiperidine

Product 1

HCID 211841683-(4-Bromo-2,6-dimethylphenoxymethyl)-1-methylpiperidine hydrochloride

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The 3-(4-bromo-2,6-dimethylphenoxymethyl)-1-methylpiperidine was treated with 1N hydrochloric acid in ether, and the precipitated salt was recrystallized from acetonitrile/tert-butyl methyl ether to yield 3-(4-bromo-2,6-dimethylphenoxymethyl)-1-methylpiperidine hydrochloride, m.p. 180.9-183.5° C.

Workup

  1. customthe precipitated salt was recrystallized from acetonitrile/tert-butyl methyl ether

Sources & evidence

ORD record
ord-5a1a489dfc674342a152d07b142905e8
Source dataset
uspto-grants-2001_07
Patent number
US06262078B1

Reaction notes

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